Fischer carbene complexes. A new tool for heterocyclic synthesis

被引：54

作者：

Barluenga, J ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, Oviedo 33071, Spain

来源：

PURE AND APPLIED CHEMISTRY | 2002年 / 74卷 / 08期

关键词：

D O I：

10.1351/pac200274081317

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This short review covers our contribution in the field of the application of group 6 Fischer carbene complexes toward the synthesis of heterocyclic compounds. Alkenyl and alkynyl carbene complexes are suitable partners in [2+2], [3+2], [4+2], and [4+3] cycloaddition reactions. Moreover, chiral alkenyl carbene complexes react in sequential processes involving an initial Michael addition of a ketone lithium enolate to afford lactones with up to five consecutive stereogenic centers. Based on this strategy, we have devised a new method for the enantio selective synthesis of eight-membered carbocycles.

引用

页码：1317 / 1325

页数：9

共 15 条

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