The determinants of dust mite allergen and its relationship to the prevalence of symptoms of asthma in the Asia-Pacific region

The role that house dust mites play in the primary causation of asthma is controversial. Approximately thirty-six 10-yr-old children in each of 10 centres in the Asia-Pacific region participated. Researchers collected dust from mattresses and living room floors using standardized procedures. Der pl and Der fl were analysed using a double monoclonal antibody enzyme-linked immunosorbent assay. Geometric mean allergen levels were calculated for each centre. 3 An ecological analysis was conducted to show the regression of the geometric mean allergen level, using the highest household level, against asthma symptom and severity prevalence data from the International Study of Asthma and Allergies in Childhood, Phase I. Among children aged 13-14 yr, the change in asthma symptom prevalence was associated with per unit change in Der p 1 mug/g (1.08, 95% CI 0.10-2.06) and Der 1 mug/g (Der pI + Der fl) (0.64, 95% Cl 0.02-1.26). The change in having four or more attacks of asthma in the last 12 months was associated with per unit change in Der p 1 mug/g (0.29, 95% CI -0.02 to 0.60) and Der 1 mug/g (0.20, 95% Cl 0.01-0.38). There was no effect for total Der pI or Der fl (total or mug/g). Among children aged 6-7 yr, neither allergen was related to symptoms or severity prevalence. While our findings suggest that Dermatophagoides pteronyssinus may have a role in the primary causation of asthma, the complexity of this association reinforces the need for prospective studies.