Mitochondrial dynamics and cancer

被引：144

作者：

Grandemange, Stephanie ^{[1
]}

Herzig, Sebastien ^{[1
]}

Martinou, Jean-Claude ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

来源：

SEMINARS IN CANCER BIOLOGY | 2009年 / 19卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Mitochondria; Fusion; Fission; Metabolism; Cancer; DEPENDENT PROTEIN-KINASE; APOPTOTIC CELL-DEATH; MARIE-TOOTH-DISEASE; INNER MEMBRANE; ATP SYNTHASE; SACCHAROMYCES-CEREVISIAE; CRISTAE MORPHOLOGY; MAMMALIAN-CELLS; GTPASE ACTIVITY; BUDDING YEAST;

D O I：

10.1016/j.semcancer.2008.12.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：50 / 56

页数：7

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