Cannabinoid receptor, CB1, expression follows neuronal differentiation in the early chick embryo

被引:53
作者
Begbie, J [1 ]
Doherty, P [1 ]
Graham, A [1 ]
机构
[1] Kings Coll London, MRC, Ctr Dev Neurobiol, Mol Neurobiol Grp, London SE1 1UL, England
关键词
CB1; endocannabinoid; neuronal differentiation;
D O I
10.1111/j.0021-8782.2004.00325.x
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
The role of the CB1 cannabinoid receptor and endocannabinoid signalling has been widely studied in the adult nervous system. However, an emerging body of evidence suggests that the CB1 receptor may also play a role during development. Here we have scrutinized the expression profile of the CB1 receptor from the onset of neurogenesis in the chick embryo. We find that this gene exhibits a dynamic expression pattern that spatially and temporally follows neuronal differentiation in the early embryo.
引用
收藏
页码:213 / 218
页数:6
相关论文
共 19 条
[1]   Early steps in the production of sensory neurons by the neurogenic placodes [J].
Begbie, J ;
Ballivet, M ;
Graham, A .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 21 (03) :502-511
[2]   Fibroblast growth factor receptor function is required for the orderly projection of ganglion cell axons in the developing mammalian retina [J].
Brittis, PA ;
Silver, J ;
Walsh, FS ;
Doherty, P .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1996, 8 (2-3) :120-128
[3]  
Buckley NE, 1998, NEUROSCIENCE, V82, P1131
[4]   Rhombomere interactions control the segmental differentiation of hindbrain neurons [J].
Eickholt, BJ ;
Graham, A ;
Lumsden, A ;
Wizenmann, A .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2001, 18 (02) :141-148
[5]   The endogenous cannabinoid system and brain development [J].
Fernández-Ruiz, J ;
Berrendero, F ;
Hernáandez, ML ;
Ramos, JA .
TRENDS IN NEUROSCIENCES, 2000, 23 (01) :14-20
[6]   Early development of the mesencephalic trigeminal nucleus [J].
Hunter, E ;
Begbie, J ;
Mason, I ;
Graham, A .
DEVELOPMENTAL DYNAMICS, 2001, 222 (03) :484-493
[7]   Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells [J].
Kreitzer, AC ;
Regehr, WG .
NEURON, 2001, 29 (03) :717-727
[8]  
Lom B, 1998, J NEUROBIOL, V37, P633, DOI 10.1002/(SICI)1097-4695(199812)37:4<633::AID-NEU11>3.0.CO
[9]  
2-L
[10]  
Mackenzie S, 1998, DEV DYNAM, V213, P349, DOI 10.1002/(SICI)1097-0177(199812)213:4<349::AID-AJA1>3.3.CO