Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100®)

被引：25

作者：

Carcao, MD

Blanchette, VS

Stephens, D

He, LJ

Wakefield, CD

Butchart, S

Christie, DJ

Rand, ML

机构：

[1] Hosp Sick Children, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Paediat, Div Haematol Oncol, Toronto, ON, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Dept Biochem, Toronto, ON, Canada

[5] Hosp Sick Children, Dept Nursing, Toronto, ON M5G 1X8, Canada

[6] Hosp Sick Children, Dept Paediat, Div Clin Epidemiol, Toronto, ON M5G 1X8, Canada

[7] Dade Behring, Miami, FL USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 117卷 / 04期

关键词：

platelet function; PFA-100((R)); thrombocytopenia; ITP;

D O I：

10.1046/j.1365-2141.2002.03511.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Platelet Function Analyzer (PFA-100((R)) ) was used to measure platelet function in paediatric patients with destructive versus underproduction thrombocytopenia. Closure time (CT) and total volume (TV) measurements with standard 150 mum apertures discriminated between patients with similar platelet counts from 30 to 150 x 10(9) /l. However, at platelet counts < 30 x 10(9) /l, a 100-mum aperture (experimental) gave the best assessment of platelet function. TV results could be analysed even when CTs were indeterminate. Further investigations are warranted to more fully understand the relationships among platelet function as measured by the PFA-100((R)) in standard/experimental modes, bleeding and transfusion outcome in thrombocytopenia.

引用

页码：961 / 964

页数：4

共 12 条

[1]

Carcao MD, 1998, BRIT J HAEMATOL, V101, P70

[2]

Escolar G, 1999, HAEMATOLOGICA, V84, P614

[3] BLEEDING TIME AS A SCREENING-TEST FOR EVALUATION OF PLATELET FUNCTION [J].