Immunological reconstitution following bone marrow transplantation

被引：128

作者：

Parkman, R

Weinberg, KI

机构：

[1] UNIV SO CALIF, SCH MED, DEPT PEDIAT, LOS ANGELES, CA 90033 USA

[2] UNIV SO CALIF, SCH MED, DEPT MICROBIOL, LOS ANGELES, CA 90033 USA

来源：

IMMUNOLOGICAL REVIEWS | 1997年 / 157卷

关键词：

D O I：

10.1111/j.1600-065X.1997.tb00975.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft-versus-host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen-specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.

引用

页码：73 / 78

页数：6

共 54 条

[11] EARLY EVENTS IN HUMAN T-CELL ONTOGENY - PHENOTYPIC CHARACTERIZATION AND IMMUNOHISTOLOGIC LOCALIZATION OF T-CELL PRECURSORS IN EARLY HUMAN-FETAL TISSUES [J].