Intestinal sugar transport

被引:171
作者
Drozdowski, Laurie A.
Thomson, Alan B. R.
机构
[1] Univ Alberta, Dept Med, Div Gastroenterol, Edmonton, AB T6G 2N8, Canada
[2] Univ Alberta, Dept Med, Div Gastroenterol, Edmonton, AB T6G 2X8, Canada
关键词
glucose; fructose; SGLT1; GLUT2; GLUT5; transport; intestine; enterocytes; sugar;
D O I
10.3748/wjg.v12.i11.1657
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Carbohydrates are an important component of the diet. The carbohydrates that we ingest range from simple monosaccharides (glucose, fructose and galactose) to disaccharides (lactose, sucrose) to complex polysaccharides. Most carbohydrates are digested by salivary and pancreatic amylases, and are further broken down into monosaccharides by enzymes in the brush border membrane (BBM) of enterocytes. For example, lactase-phloridzin hydrolase and sucrase-isomaltase are two disaccharidases involved in the hydrolysis of nutritionally important disaccharides. Once monosaccharides are presented to the BBM, mature enterocytes expressing nutrient transporters transport the sugars into the enterocytes. This paper reviews the early studies that contributed to the development of a working model of intestinal sugar transport, and details the recent advances made in understanding the process by which sugars are absorbed in the intestine. (c) 2006 The WJG Press. All rights reserved.
引用
收藏
页码:1657 / 1670
页数:14
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