Shell cross-linked nanoparticles designed to target angiogenic blood vessels via αvβ3 receptor-ligand interactions

被引：56

作者：

Pan, DJ

Turner, JL

Wooley, KL

机构：

[1] Washington Univ, Ctr Mat Innovat, St Louis, MO 63130 USA

[2] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

MACROMOLECULES | 2004年 / 37卷 / 19期

关键词：

D O I：

10.1021/ma048824e

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

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收藏

页码：7109 / 7115

页数：7

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