The effect of diet on plasma homocysteine concentrations in healthy male subjects

被引:78
作者
Mann, NJ
Li, D
Sinclair, AJ
Dudman, NPB
Guo, XW
Elsworth, GR
Wilson, AK
Kelly, FD
机构
[1] RMIT Univ, Dept Food Sci, Melbourne, Vic 3001, Australia
[2] Univ New S Wales, Ctr Thrombosis & Vasc Res, Dept Cardiovasc Med, Sydney, NSW, Australia
[3] Univ Melbourne, Ctr Program Evaluat, Melbourne, Vic, Australia
关键词
homocysteine; folate; vitamin B-12; methionine; cysteine; trans-sulphuration; remethylation; ovolacto-vegetarian; vegan; vitamin B-6 hyperhomocyseinemia; omnivore; vascular disease;
D O I
10.1038/sj.ejcn.1600874
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To determine the effect of habitual omnivorous and vegetarian diets on folate and Vitamin Bit status and the subsequent effect on homocysteine concentration. Design: Cross-sectional comparison of free-living habitual meat-eaters and habitual vegetarians. Setting: The study was conducted at RMIT University, Melbourne. Subjects: One hundred and thirty-nine healthy male subjects (vegans n = 18, ovolacto vegetarians n = 43, moderate meat-eaters n = 60 and high meat-eaters n = 18) aged 20-55 y who were recruited in Melbourne. Outcome measures: Fasting plasma or serum from each subject was analysed for folate, vitamin B-12 and homocysteine concentration. A semi-quantitative Food Frequency Questionnaire was completed by a subset of subjects from each group to determine methionine intake. Results: The two meat eating groups consumed significantly greater levels of methionine (P < 0.001), There was no clear trend in plasma folate status between groups, however the plasma vitamin B-12 concentration decreased progressively from the high-meat-eating group to vegans (P < 0.05). An inverse trend was observed with plasma homocysteine concentration, with vegans showing the highest levels and high meat eaters the lowest (P < 0.05). Conclusions: Dietary methionine intake has no observable effect on plasma homocysteine concentration. In habitual diets, where folate intake is adequate, lowered vitamin B-12 intake from animal foods leads to depleted plasma vitamin B-12 concentration with a concomitant increase in homocysteine concentration. The suggested mechanism is the failure to transfer a methyl group from methyl tetrahydrofolate by vitamin B-12 in the remethylation of homocysteine of homocysteine to methionine. Sponsorship: The study was funded by the Meat Research Corporation of Australia. Descriptors: homocysteine; folate; vitamin B-12; methionine; cysteine; trans-sulphuration; remethylation; ovolacto-vegetarian; vegan; vitamin B-6 hyperhomocyseinemia; omnivore; vascular disease.
引用
收藏
页码:895 / 899
页数:5
相关论文
共 30 条
  • [21] Vitamin intake: A possible determinant of plasma homocyst(e)ine among middle-aged adults
    Shimakawa, T
    Nieto, FJ
    Malinow, MR
    Chambless, LE
    Schreiner, PJ
    Szklo, M
    [J]. ANNALS OF EPIDEMIOLOGY, 1997, 7 (04) : 285 - 293
  • [22] ELEVATION OF TOTAL HOMOCYSTEINE IN THE SERUM OF PATIENTS WITH COBALAMIN OR FOLATE-DEFICIENCY DETECTED BY CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    STABLER, SP
    MARCELL, PD
    PODELL, ER
    ALLEN, RH
    SAVAGE, DG
    LINDENBAUM, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (02) : 466 - 474
  • [23] A PROSPECTIVE-STUDY OF PLASMA HOMOCYST(E)INE AND RISK OF MYOCARDIAL-INFARCTION IN UNITED-STATES PHYSICIANS
    STAMPFER, MJ
    MALINOW, MR
    WILLETT, WC
    NEWCOMER, LM
    UPSON, B
    ULLMANN, D
    TISHLER, PV
    HENNEKENS, CH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (07): : 877 - 881
  • [24] Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart Study
    Tucker, KL
    Selhub, J
    Wilson, PWF
    Rosenberg, IH
    [J]. JOURNAL OF NUTRITION, 1996, 126 (12) : 3025 - 3031
  • [25] VITAMIN REQUIREMENTS FOR THE TREATMENT OF HYPERHOMOCYSTEINEMIA IN HUMANS
    UBBINK, JB
    VERMAAK, WJH
    VANDERMERWE, A
    BECKER, PJ
    DELPORT, R
    POTGIETER, HC
    [J]. JOURNAL OF NUTRITION, 1994, 124 (10) : 1927 - 1933
  • [26] UBBINK JB, 1993, CLIN INVESTIGATOR, V71, P993, DOI 10.1007/BF00180030
  • [27] Ueland P.M., 1992, ARTERIOSCLEROTIC CAR, P183
  • [28] A PROSPECTIVE-STUDY OF PLASMA HOMOCYST(E)INE AND RISK OF ISCHEMIC STROKE
    VERHOEF, P
    HENNEKENS, CH
    MALINOW, MR
    KOK, FJ
    WILLETT, WC
    STAMPFER, MJ
    [J]. STROKE, 1994, 25 (10) : 1924 - 1930
  • [29] Verhoef P, 1996, AM J EPIDEMIOL, V143, P845, DOI 10.1093/oxfordjournals.aje.a008828
  • [30] PATHOGENESIS OF CORONARY-ARTERY DISEASE - POSSIBLE ROLE FOR METHIONINE METABOLISM
    WILCKEN, DEL
    WILCKEN, B
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (04) : 1079 - 1082