The delineation of target volumes for radiotherapy of lung cancer patients

被引：67

作者：

Vorwerk, Hilke ^{[1
]}

Beckmann, Gabriele ^{[2
]}

Bremer, Michael ^{[3
]}

Degen, Maria ^{[4
]}

Dietl, Barbara ^{[5
]}

Fietkau, Rainer ^{[6
]}

Gsaenger, Tammo ^{[1
]}

Hermann, Robert Michael ^{[1
]}

Herrmann, Markus Karl Alfred ^{[1
]}

Hoeller, Ulrike ^{[7
]}

van Kampen, Michael ^{[8
]}

Koerber, Wolfgang ^{[9
]}

Maier, Burkhard ^{[10
]}

Martin, Thomas ^{[11
]}

Metz, Michael ^{[12
]}

Richter, Ronald ^{[13
]}

Siekmeyer, Birgit ^{[1
]}

Steder, Martin ^{[14
]}

Wagner, Daniela ^{[1
]}

Hess, Clemens Friedrich ^{[1
]}

Weiss, Elisabeth ^{[1
,15
]}

Christiansen, Hans ^{[1
]}

机构：

[1] Univ Hosp Gottingen, Dept Radiotherapy & Radiooncol, D-37099 Gottingen, Germany

[2] Univ Hosp Wurzburg, Dept Radiotherapy & Radiooncol, Wurzburg, Germany

[3] Hannover Med Sch, Dept Radiotherapy & Radiooncol, Hannover, Germany

[4] Lungenfachklin, Dept Pneumol, Waldhof Elgershausen, Greifenstein, Germany

[5] Univ Hosp Regensburg, Dept Radiotherapy & Radiooncol, Regensburg, Germany

[6] Univ Hosp Erlangen, Dept Radiotherapy & Radiooncol, Erlangen, Germany

[7] Vivantes MVZ Neukolin, Dept Radiotherapy & Radiooncol, Berlin, Germany

[8] Krankenhaus NW Frankfurt, Dept Radiotherapy & Radiooncol, Frankfurt, Germany

[9] Ev Krankenhaus Weende, Dept Pneumol, Pappelweg, Bovenden Lengle, Germany

[10] Klinikum Bayreuth, Dept Radiotherapy & Radiooncol, Bayreuth, Germany

[11] Klinikum Bremen Mitte, Dept Radiotherapy & Radiooncol, Bremen, Germany

[12] Univ Hosp Gottingen, Dept Haematooncol, D-37099 Gottingen, Germany

[13] Klinikum St Georg, Dept Radiotherapy & Radiooncol, Leipzig, Germany

[14] Pius Hosp, Dept Haematooncol, Oldenburg, Germany

[15] Virginia Commonwealth Univ, Dept Radiat Oncol, Richmond, VA USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2009年 / 91卷 / 03期

关键词：

Radiation therapy; Lung cancer; Interobserver variability; Delineation; Target volume; GROSS TUMOR VOLUME; CONFORMAL RADIOTHERAPY; QUALITY-ASSURANCE; INTEROBSERVER VARIABILITY; RADIATION ONCOLOGISTS; DUMMY RUN; CT; DEFINITION; TRIAL; PET;

D O I：

10.1016/j.radonc.2009.03.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods: In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and M in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results: Agreement (overlap >= 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion: A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group RO1D where due to repeated discussions and uniform teaching a better agreement was achieved. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 455-460

引用

页码：455 / 460

页数：6

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