The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder

被引：51

作者：

Hollander, E ^{[1
]}

Novotny, S ^{[1
]}

Allen, A ^{[1
]}

Aronowitz, B ^{[1
]}

Cartwright, C ^{[1
]}

DeCaria, C ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Seaver Autism Res Ctr, Dept Psychiat, New York, NY 10029 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2000年 / 22卷 / 02期

关键词：

autism; Asperger's disorder; serotonin; sumatriptan; growth hormone; repetitive behavior;

D O I：

10.1016/S0893-133X(99)00121-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism is heterogeneous with respect to clinical symptoms and etiology. To sort out this heterogeneity in autism, we investigated whether specific neurobiological markers vary in parallel to cove symptomatology. Specifically, we assessed growth hormone response to the 5-HT Id agonist, sumatriptan, and linked this measure of serotonergic function to the severity of repetitive behaviors in adult autistic patients. Eleven adult patients with autism or Asperger's disorder were randomized to single dose sumatriptan (6 mg SQ) and placebo challenges, separated by a one-week interval. In adult autistic disorders, severity of repetitive behaviors at baseline, as measured by YBOCS-compulsion score, significantly positively correlated with both peak delta growth hormone response and area under the curve growth hormone response to sumatriptan. Thus, the severity of a specific behavioral dimension in autism (repetitive behaviors) parallels the sensitivity of the 5-HT Id receptor,. as manifest by sumatriptan elicited GH response. (C)1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：163 / 167

页数：5

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