c-Fos transrepression revisited

被引：5

作者：

Cahill, MA

机构：

[1] Transcriptional Regulation Group, Div. of Immunology and Cell Biology, Australian National University, Canberra, ACT

来源：

FEBS LETTERS | 1997年 / 400卷 / 01期

关键词：

transcription regulation; transcription factor; transcription coactivator; Fos; AP-1;

D O I：

10.1016/S0014-5793(96)01349-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to, deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.

引用

页码：9 / 10

页数：2

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