Peptide templated glycosylation reactions

被引：49

作者：

Tennant-Eyles, RJ

Davis, BG

Fairbanks, AJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(99)00494-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Glycosyl donors and accepters may be covalently linked to aspartic acid residues via OH-6 esters. Peptide elaboration allows glycosylation reactions to be performed between donors and accepters linked to this peptide template. These reactions display increased regio- and stereoselectivities, which are dependent on the nature of the peptide. Simple molecular modelling is used to rationalise the differing product distributions obtained by variation of the linking amino acid sequence. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：231 / 243

页数：13