Hypoxia and angiogenesis in pancreatic cancer

被引：39

作者：

Garcea, Giuseppe ^{[1
]}

Doucas, Helena ^{[1
]}

Steward, Will P. ^{[1
]}

Dennison, Ashley R. ^{[1
]}

Berry, David P. ^{[1
]}

机构：

[1] Leicester Gen Hosp, Dept Hepatobiliary Surg, Leicester LE5 4PW, Leics, England

来源：

ANZ JOURNAL OF SURGERY | 2006年 / 76卷 / 09期

关键词：

hypoxia; angiogenesis; pancreatic cancer;

D O I：

10.1111/j.1445-2197.2006.03872.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Pancreatic cancer remains one of the most lethal of all solid tumours of the gastrointestinal tract. It is characterized by late diagnosis, aggressive local invasion, early metastasis and resistance to chemoradiotherapy. Increasing knowledge regarding the molecular events behind the growth and invasion of pancreatic cancer may lead to new targets for intervention. Methods: A search of Pubmed and Medline databases was undertaken using the keywords pancreatic cancer, gastrointestinal cancer, hypoxia, angiogenesis and anti-angiogenesis therapy. Results: Hypoxia is the driving force behind angiogenesis in pancreatic cancers. Research into angiogenesis has shown many different sites that can be targeted by agents such as tyrosine kinase inhibitors. Conclusion: Anti-angiogenic therapy could be an important adjunct to conventional chemotherapy treatment of gastrointestinal neoplasia.

引用

页码：830 / 842

页数：13

共 153 条

[1]

Akakura N, 2001, CANCER RES, V61, P6548

[2]

[Anonymous], NIH PUBLICATION

[3]

[Anonymous], 1994, RADIOBIOLOGY RADIOLO

[4]

[Anonymous], 1997, BIOCH BIOPHYSICA ACT

[5]

Aoki T, 2002, ONCOL REP, V9, P761

[6]

BAENZIGER NL, 1972, J BIOL CHEM, V247, P2723

[7]

Baker CH, 2002, CANCER RES, V62, P1996

[8] INSULIN-LIKE GROWTH-FACTOR-I, INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA IN PANCREATIC-CANCER - ROLE IN TUMOR INVASIVENESS AND ASSOCIATED DIABETES [J].

BASSO, D ;

PLEBANI, M ;

FOGAR, P ;

PANOZZO, MP ;

MEGGIATO, T ;

DEPAOLI, M .

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1995, 25 (01) :40-43

[9]

Beasley NJP, 2001, CANCER RES, V61, P5262

[10] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].

Bergers, G ;

Brekken, R ;

McMahon, G ;

Vu, TH ;

Itoh, T ;

Tamaki, K ;

Tanzawa, K ;

Thorpe, P ;

Itohara, S ;

Werb, Z ;

Hanahan, D .

NATURE CELL BIOLOGY, 2000, 2 (10) :737-744

← 1 2 3 4 5 6 7 8 9 10 →