Hypoxia and angiogenesis in pancreatic cancer

被引：39

作者：

Garcea, Giuseppe ^{[1
]}

Doucas, Helena ^{[1
]}

Steward, Will P. ^{[1
]}

Dennison, Ashley R. ^{[1
]}

Berry, David P. ^{[1
]}

机构：

[1] Leicester Gen Hosp, Dept Hepatobiliary Surg, Leicester LE5 4PW, Leics, England

来源：

ANZ JOURNAL OF SURGERY | 2006年 / 76卷 / 09期

关键词：

hypoxia; angiogenesis; pancreatic cancer;

D O I：

10.1111/j.1445-2197.2006.03872.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Pancreatic cancer remains one of the most lethal of all solid tumours of the gastrointestinal tract. It is characterized by late diagnosis, aggressive local invasion, early metastasis and resistance to chemoradiotherapy. Increasing knowledge regarding the molecular events behind the growth and invasion of pancreatic cancer may lead to new targets for intervention. Methods: A search of Pubmed and Medline databases was undertaken using the keywords pancreatic cancer, gastrointestinal cancer, hypoxia, angiogenesis and anti-angiogenesis therapy. Results: Hypoxia is the driving force behind angiogenesis in pancreatic cancers. Research into angiogenesis has shown many different sites that can be targeted by agents such as tyrosine kinase inhibitors. Conclusion: Anti-angiogenic therapy could be an important adjunct to conventional chemotherapy treatment of gastrointestinal neoplasia.

引用

页码：830 / 842

页数：13

共 153 条

[41] Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis [J].

Fujimoto, K ;

Hosotani, R ;

Wada, M ;

Lee, JU ;

Koshiba, T ;

Miyamoto, Y ;

Tsuji, S ;

Nakajima, S ;

Doi, R ;

Imamura, M .

EUROPEAN JOURNAL OF CANCER, 1998, 34 (09) :1439-1447

[42]

Fujioka S, 2001, CANCER, V92, P1788, DOI 10.1002/1097-0142(20011001)92:7<1788::AID-CNCR1695>3.0.CO

[43]

2-Z

[44] Receptors for collapsin/semaphorins [J].

Fujisawa, H ;

Kitsukawa, T .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (05) :587-592

[45]

GHANEH P, 2004, SURG ONCOL CLIN N AM, V4, P567

[46]

Giatromanolaki A, 2001, ANTICANCER RES, V21, P4317

[47] Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [J].

Graeber, TG ;

Osmanian, C ;

Jacks, T ;

Housman, DE ;

Koch, CJ ;

Lowe, SW ;

Giaccia, AJ .

NATURE, 1996, 379 (6560) :88-91

[48] THE CONCENTRATION OF OXYGEN DISSOLVED IN TISSUES AT THE TIME OF IRRADIATION AS A FACTOR IN RADIOTHERAPY [J].

GRAY, LH ;

CONGER, AD ;

EBERT, M ;

HORNSEY, S ;

SCOTT, OCA .

BRITISH JOURNAL OF RADIOLOGY, 1953, 26 (312) :638-648

[49]

Griffin RJ, 2002, CANCER RES, V62, P1702

[50] Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression [J].

Hansel, DE ;

Rahman, A ;

Hermans, J ;

de Krijger, RR ;

Ashfaq, R ;

Yeo, CJ ;

Cameron, JL ;

Maitra, A .

MODERN PATHOLOGY, 2003, 16 (07) :652-659

← 1 2 3 4 5 6 7 8 9 10 →