Neutropenic enterocolitis (typhi litis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature

被引：24

作者：

D'Amato, G

Lima, CR

Mahany, JJ

Muro-Cacho, C

Haura, EB

机构：

[1] H Lee Moffit Canc Ctr & Res Inst, Expt Therapeut Program, Tampa, FL 33612 USA

[2] H Lee Moffit Canc Ctr & Res Inst, Thorac Oncol Program, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

[4] Univ S Florida, Coll Med, Dept Pathol, Tampa, FL 33612 USA

[5] Univ Miami, Sylvester Canc Ctr, Dept Med, Div Hematol Oncol, Miami, FL 33152 USA

来源：

LUNG CANCER | 2004年 / 44卷 / 03期

关键词：

typhlitis; neutropenic; enterocolitis; lung; cancer; taxanes; chemotherapy;

D O I：

10.1016/j.lungcan.2003.11.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neutropenic enterocolitis (NE) is an unusual acute complication of neutropenia, most often associated with leukemia and lymphoma which is characterized by segmental cecal and ascending colon ulceration that may progress to necrosis, perforation, and septicemia. We present a case of neutropenic enterocolitis in a patient with non-small-cell lung cancer who received docetaxel and flavopiridol as part of a phase I clinical trial and review cases in the literature where docetaxel was involved. Given the increased use of docetaxel and other taxanes in the treatment of advanced lung cancer, physicians should be aware of this potential toxicity of therapy. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：381 / 390

页数：10

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