PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2

被引:32
作者
Jiménez-Lara, AM [1 ]
Heine, MJS [1 ]
Gronemeyer, H [1 ]
机构
[1] Coll France, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France
来源
FEBS LETTERS | 2002年 / 526卷 / 1-3期
关键词
TIF2; nuclear receptor; protein inhibitor of activated STAT-3; transcriptional modulator;
D O I
10.1016/S0014-5793(02)03154-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors. The interaction is mediated by two distinct non-contiguous regions of TIF2. We found that TIF2-PIAS3 interaction occurs through a unique domain of PIAS3, very rich in acidic residues and conserved throughout the PIAS family. PIAS3 modulates the ability of TIF2 to mediate ligand-enhanced transcription activation positively or negatively, for different steroid receptors. Taken together, our results indicate a potential role of PIAS3 as transcriptional modulator of TIF2-mediated signalling. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:142 / 146
页数:5
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