First syntheses of two quinoline alkaloids from the medicinal herb Ruta Chalepensis via cyclization of an o-iodoaniline with an acetylenic sulfone

被引：15

作者：

Back, TG ^{[1
]}

Wulff, JE ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 16期

关键词：

D O I：

10.1039/b205408f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first syntheses of two quinoline alkaloids found in the medicinal herb Ruta chalepensis are reported via the conjugate addition of an o-iodoaniline to an acetylenic sulfone, followed by Pd-catalyzed carbonylation, intramolecular acylation of the coresponding sulfo ne-stabilized carbanion, and reductive desulfonylation.

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页码：1710 / 1711

页数：2

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