Class II-independent generation of CD4 memory T cells from effecters

被引：349

作者：

Swain, SL ^{[1
]}

Hu, H ^{[1
]}

Huston, G ^{[1
]}

机构：

[1] Trudeau Inst Inc, Biomed Res Labs, Saranac Lake, NY 12983 USA

来源：

SCIENCE | 1999年 / 286卷 / 5443期

关键词：

D O I：

10.1126/science.286.5443.1381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effecters generated in vitro from naive CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class ii recognition.

引用

页码：1381 / 1383

页数：3

共 22 条

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