Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

被引：34

作者：

Gordon, Stephen V. ^{[1
,2
]}

Bottai, Daria ^{[3
]}

Simeone, Roxane ^{[4
]}

Stinear, Timothy P. ^{[5
]}

Brosch, Roland ^{[4
]}

机构：

[1] Univ Coll Dublin, UCD Coll Life Sci, Dublin 2, Ireland

[2] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin 2, Ireland

[3] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, Pisa, Italy

[4] UP Pathogenom Mycobacterienne Integree, Inst Pasteur, Paris, France

[5] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia

来源：

BIOESSAYS | 2009年 / 31卷 / 04期

基金：

英国医学研究理事会;

关键词：

BCG; evolution; mycobacteria; pathogenesis; tuberculosis; MYCOBACTERIUM-TUBERCULOSIS COMPLEX; COMPLETE GENOME SEQUENCE; T-CELL ANTIGEN; TRANSCRIPTION FACTOR; CALMETTE-GUERIN; BOVIS BCG; IMMUNE-RESPONSES; GENE-CLUSTER; SECRETION; VIRULENCE;

D O I：

10.1002/bies.200800191

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.

引用

页码：378 / 388

页数：11

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