Hybrid biocomposites based on calcium phosphate mineralization of self-assembled supramolecular hydrogels

被引:134
作者
Schnepp, Zoe A. C. [1 ]
Gonzalez-McQuire, Rosanna [1 ]
Mann, Stephen [1 ]
机构
[1] Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS8 1TS, Avon, England
关键词
D O I
10.1002/adma.200502545
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Mineralization of small-molecule-based supramolecular hydrogels with calcium phosphate produces hybrid composites comprising interconnecting networks of calcified nanofilaments (see figure). Viscoelastic hybrid gels that exhibit enhanced thermal stability, stiffness, and critical strain are formed at low mineral contents, whereas extensive mineralization generates hard macroporous replicas of the supramolecular matrix.
引用
收藏
页码:1869 / +
页数:5
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共 12 条
  • [1] Tissue engineering scaffold material of nano-apatite crystals and polyamide composite
    Jie, W
    Li, Y
    [J]. EUROPEAN POLYMER JOURNAL, 2004, 40 (03) : 509 - 515
  • [2] Semi-wet peptide/protein array using supramolecular hydrogel
    Kiyonaka, S
    Sada, K
    Yoshimura, I
    Shinkai, S
    Kato, N
    Hamachi, I
    [J]. NATURE MATERIALS, 2004, 3 (01) : 58 - 64
  • [3] Hydrogel formation via cell crosslinking
    Lee, KY
    Kong, HJ
    Larson, RG
    Mooney, DJ
    [J]. ADVANCED MATERIALS, 2003, 15 (21) : 1828 - 1832
  • [4] Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide) and α-cyclodextrin
    Li, J
    Ni, XP
    Leong, KW
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 65A (02): : 196 - 202
  • [5] Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture
    van Bommel, KJC
    van der Pol, C
    Muizebelt, I
    Friggeri, A
    Heeres, A
    Meetsma, A
    Feringa, BL
    van Esch, J
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (13) : 1663 - 1667
  • [6] Organic templates for the generation of inorganic materials
    van Bommel, KJC
    Friggeri, A
    Shinkai, S
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (09) : 980 - 999
  • [7] Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering
    Wei, GB
    Ma, PX
    [J]. BIOMATERIALS, 2004, 25 (19) : 4749 - 4757
  • [8] Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds
    Yang, ZM
    Xu, KM
    Wang, L
    Gu, HW
    Wei, H
    Zhang, MJ
    Xu, B
    [J]. CHEMICAL COMMUNICATIONS, 2005, (35) : 4414 - 4416
  • [9] A simple visual assay based on small molecule hydrogels for detecting inhibitors of enzymes
    Yang, ZM
    Xu, B
    [J]. CHEMICAL COMMUNICATIONS, 2004, (21) : 2424 - 2425
  • [10] Enzymatic formation of supramolecular hydrogels
    Yang, ZM
    Gu, HW
    Fu, DG
    Gao, P
    Lam, JK
    Xu, B
    [J]. ADVANCED MATERIALS, 2004, 16 (16) : 1440 - +