Gene networks: how to put the function in genomics

被引:166
作者
Brazhnik, P [1 ]
de la Fuente, A [1 ]
Mendes, P [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0167-7799(02)02053-X
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
An increasingly popular model of regulation is to represent networks of genes as if they directly affect each other. Although such gene networks are phenomenological because they do not explicitly represent the proteins and metabolites that mediate cell interactions, they are a logical way of describing phenomena observed with transcription profiling, such as those that occur with popular microarray technology. The ability to create gene networks from experimental data and use them to reason about their dynamics and design principles will increase our understanding of cellular function. We propose that gene networks are also a good way to describe function unequivocally, and that they could be used for genome functional annotation. Here, we review some of the concepts and methods associated with gene networks, with emphasis on their construction based on experimental data.
引用
收藏
页码:467 / 472
页数:6
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