Mechanisms of Transcranial Magnetic Stimulation Treating on Post-stroke Depression

被引：54

作者：

Duan, Xiaoqin ^{[1
]}

Yao, Gang ^{[1
]}

Liu, Zhongliang ^{[1
]}

Cui, Ranji ^{[1
]}

Yang, Wei ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Jilin, Peoples R China

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2018年 / 12卷

基金：

中国国家自然科学基金;

关键词：

noninvasive brain stimulation; transcranial magnetic stimulation; post-stroke depression; mechanism; BDNF; THETA-BURST STIMULATION; MOTOR CORTEX PLASTICITY; NEUROTROPHIC FACTOR; MAJOR DEPRESSION; HF-RTMS; BRAIN; STROKE; METAANALYSIS; EFFICACY;

D O I：

10.3389/fnhum.2018.00215

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Post-stroke depression (PSD) is a neuropsychiatric affective disorder that can develop after stroke. Patients with PSD show poorer functional and recovery outcomes than patients with stroke who do not suffer from depression. The risk of suicide is also higher in patients with PSD. PSD appears to be associated with complex pathophysiological mechanisms involving both psychological and psychiatric problems that are associated with functional deficits and neurochemical changes secondary to brain damage. Transcranial magnetic stimulation (TMS) is a non-invasive way to investigate cortical excitability via magnetic stimulation of the brain. TMS is currently a valuable tool that can help us understand the pathophysiology of PSD. Although repetitive TMS (rTMS) is an effective treatment for patients with PSD, its mechanism of action remains unknown. Here, we review the known mechanisms underlying rTMS as a tool for better understanding PSD pathophysiology. It should be helpful when considering using rTMS as a therapeutic strategy for PSD.

引用

页数：6

共 64 条

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The molecular evidence of neural plasticity induced by cerebellar repetitive transcranial magnetic stimulation in the rat brain: A preliminary report [J].