Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae

被引：54

作者：

Baranwal, S

Dey, K

Ramamurthy, T

Nair, GB

Kundu, M

机构：

[1] Bose Inst, Dept Chem, Kolkata 700009, India

[2] Natl Inst Cholera & Enter Dis, Beleghata 700010, Kolkata, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 08期

关键词：

D O I：

10.1128/AAC.46.8.2676-2678.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.

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页码：2676 / 2678

页数：3

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