Peroxisome membrane biogenesis: The stage is set

被引：39

作者：

Schliebs, W ^{[1
]}

Kunau, WH ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Inst Physiol Chem, D-44780 Bochum, Germany

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.cub.2004.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pex3p and Pex19p are key players in the post-translational import of peroxisomal membrane proteins. New data suggest that these peroxins act in tandem, Pex19p as a cytosolic chaperone and import receptor for peroxisomal membrane proteins, and Pex3p as docking factor at the peroxisomal membrane.

引用

页码：R397 / R399

页数：3

共 20 条

[1] Peroxisome biogenesis occurs in an unsynchronized manner in close association with the endoplasmic reticulum in temperature-sensitive Yarrowia lipolytica Pex3p mutants [J].

Bascom, RA ;

Chan, H ;

Rachubinski, RA .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :939-957

[2] Peroxisome biogenesis and the role of protein import [J].

Brown, LA ;

Baker, A .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2003, 7 (04) :388-400

[3] Peroxisome biogenesis [J].

Eckert, JH ;

Erdmann, R .

REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 147 2003, 2003, 147 :75-121

[4] PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins [J].

Fang, Y ;

Morrell, JC ;

Jones, JM ;

Gould, SJ .

JOURNAL OF CELL BIOLOGY, 2004, 164 (06) :863-875

[5] Potential role for Pex19p in assembly of PTS-receptor docking complexes [J].

Fransen, M ;

Vastiau, I ;

Brees, C ;

Brys, V ;

Mannaerts, GP ;

Van Veldhoven, PP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12615-12624

[6] Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences [J].

Fransen, M ;

Wylin, T ;

Brees, C ;

Mannaerts, GP ;

Van Veldhoven, PP .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (13) :4413-4424

[7]

Götte K, 1998, MOL CELL BIOL, V18, P616

[8] Peroxisome remnants in pex3Δ cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes [J].

Hazra, PP ;

Suriapranata, I ;

Snyder, WB ;

Subramani, S .

TRAFFIC, 2002, 3 (08) :560-574

[9] Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins [J].

Hettema, EH ;

Girzalsky, W ;

van den Berg, M ;

Erdmann, R ;

Distel, B .

EMBO JOURNAL, 2000, 19 (02) :223-233

[10] PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins [J].

Jones, JM ;

Morrell, JC ;

Gould, SJ .

JOURNAL OF CELL BIOLOGY, 2004, 164 (01) :57-67

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