A critical review of the state of the art of solid-phase microextraction of complex matrices III. Bioanalytical and clinical applications

被引：204

作者：

Souza-Silva, Erica A. ^{[1
]}

Reyes-Garces, Nathaly ^{[1
]}

Gomez-Rios, German A. ^{[1
]}

Boyaci, Ezel ^{[1
]}

Bojko, Barbara ^{[1
,2
]}

Pawliszyn, Janusz ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

[2] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Pharm, Dept Pharmacodynam & Mol Pharmacol, Torun, Poland

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2015年 / 71卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Bioanalytical and clinical analysis; Blood; Complex matrix; Drug; High throughput; In-vivo sampling; Metabolomics; Solid-phase microextraction; Tissue; Urine; TANDEM MASS-SPECTROMETRY; ION MOBILITY SPECTROMETRY; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; TRANEXAMIC ACID CONCENTRATION; SAMPLE PREPARATION TECHNIQUES; VOLATILE ORGANIC-COMPOUNDS; HIGH-THROUGHPUT ANALYSIS; REAL-TIME DART; IN-TIP SPME; LIQUID-CHROMATOGRAPHY;

D O I：

10.1016/j.trac.2015.04.017

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Part III of this review focuses on the state of the art of solid-phase microextraction (SPME) applied to bioanalytical and clinical analysis. We describe and discuss recent applications and new advances in terms of extraction phases and SPME configurations. Biocompatible coatings for the direct extraction of different analytes from urine, blood and tissues are perhaps the most promising approach in SPME. We present a review of the different calibration strategies commonly employed, and a discussion on the advantages and the disadvantages of SPME related to the analysis of these biological matrices. (C) 2015 Elsevier B.V. All rights reserved,

引用

页码：249 / 264

页数：16

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