Solid-phase microextraction in metabolomics

被引：115

作者：

Bojko, Barbara ^{[1
,2
]}

Reyes-Garces, Nathaly ^{[1
]}

Bessonneau, Vincent ^{[1
]}

Gorynski, Krzysztof ^{[1
,2
]}

Mousavi, Fatemeh ^{[1
]}

Silva, Erica A. Souza ^{[1
]}

Pawliszyn, Janusz ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

[2] Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Med Chem, Torun, Poland

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2014年 / 61卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Blood; Cell culture; Extraction phase; In vivo; Metabolomics; Plant; Plasma; Solid-phase microextraction; Tissue; Urine; VOLATILE ORGANIC-COMPOUNDS; 2-DIMENSIONAL GAS-CHROMATOGRAPHY; FLIGHT MASS-SPECTROMETRY; LUNG-CANCER; BIOLOGICAL SAMPLES; BANANA CULTIVARS; EXHALED BREATH; POWERFUL TOOL; GC-MS; HEADSPACE;

D O I：

10.1016/j.trac.2014.07.005

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Among all the "-omics" studies, metabolomics currently has the most growth potential. The complexity of the studied matrices demands from the analytical chemist the development of new protocols and the modification of existing methods to obtain a full biochemical image of the sample. In the current review, we discuss the advantages and the disadvantages of solid-phase microextraction based on up-to-date metabolomics studies performed on plants, biofluids, tissues and cell cultures. We place particular emphasis on the development of new extraction phases in view of the analyte coverage and on the features of the method, which complement solvent-based extraction technologies. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：168 / 180

页数：13

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