Increased risk of maternal-infant hepatitis C virus transmission for women coinfected with human immunodeficiency virus type I

被引:122
作者
Tovo, PA
Palomba, E
Ferraris, G
Principi, N
Ruga, E
Dallacasa, P
Maccabruni, A
Rancilio, L
Bucceri, A
Tagger, A
Riva, C
Scolfaro, C
Madon, E
Zuin, G
Boschetti, M
Tessarotto, L
Bosi, I
Bossi, G
Stegagno, M
Quinti, I
Fundaro, C
Marcellini, M
Costa, R
Busti, G
Salvi, C
机构
[1] USSL 75I,MATERNAL INFANT CTR,MILAN,ITALY
[2] UNIV MILAN,DEPT PEDIAT 4,MILAN,ITALY
[3] UNIV PADUA,DEPT PEDIAT,PADUA,ITALY
[4] UNIV PAVIA,IRCCS,INST INFECT DIS,I-27100 PAVIA,ITALY
[5] UNIV BOLOGNA,DEPT PEDIAT,BOLOGNA,ITALY
关键词
D O I
10.1086/516102
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To estimate the risk of mother-to-child transmission of hepatitis C virus (HCV) and identify correlates of transmission, 245 perinatally exposed singleton children followed prospectively beyond 18 months of age were studied, Overall, 28 (11.4%) of the 245 children acquired HCV infection. Transmission occurred in 3 of 80 children (3.7%) whose mothers had HCV infection alone and in 25 of 165 (15.1%; P < .01) whose mothers had concurrent infection with human immunodeficiency virus type 1 (HIV-1), The percentage of HIV-1-infected children was similar (22 of 165, 13.3%), but each virus was transmitted independently; only six infants (3.6%) were coinfected with HCV and HIV-1. The risk of HCV transmission was not associated with maternal HIV-l-related symptoms, intravenous drug use, prematurity, low birth weight, or breast-feeding, whereas it was lower with cesarean section than with vaginal delivery (5.6% vs. 13.9%, P = .06). This suggests that transmission occurs mainly around the time of delivery.
引用
收藏
页码:1121 / 1124
页数:4
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