The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

被引：148

作者：

Xing, XM

Wang, SC

Xia, WY

Zou, YY

Shao, RP

Kwong, KY

Yu, ZM

Zhang, S

Miller, S

Huang, L

Hung, MC

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Sect Mol Cell Biol, Houston, TX 77030 USA

[2] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1038/72294

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER-2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

引用

页码：189 / 195

页数：7

共 48 条

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