Phosphoinositides and the endocytic pathway

被引：36

作者：

Clague, Michael J. ^{[1
]}

Urbe, Sylvie ^{[1
]}

de Lartigue, Jane ^{[1
]}

机构：

[1] Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 09期

基金：

英国惠康基金;

关键词：

Endocytosis; Phosphoinositide; EEA1; Hrs; Sorting nexin; PI; 3-kinase; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; MANNOSE 6-PHOSPHATE RECEPTORS; CLATHRIN-MEDIATED ENDOCYTOSIS; COATED PITS; SCHIZOSACCHAROMYCES-POMBE; SUBSTRATE-SPECIFICITY; MULTIVESICULAR BODY; LIPID PHOSPHATASES; PLASMA-MEMBRANE; ENDOSOME FUSION;

D O I：

10.1016/j.yexcr.2008.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Phosphorylation of the phosphatidylinositol headgroup generates seven varieties of phosphoinositide of which PtdIns(4,5)P-2, PtdIns3P and PtdIns (3,5)P-2 have established roles on the endocytic pathway. In this review, we discuss the enzymes responsible for generation and turnover of these lipids, which are keys to determining compartmental identity and the flux of material through the endocytic system. The enzymatic generation of lipids serves as an amplification mechanism through which a wide variety of effector molecules can be recruited. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1627 / 1631

页数：5

共 67 条

[1] Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor [J].

Abe, Namiko ;

Inoue, Takanari ;

Galvez, Thierry ;

Klein, Lawrence ;

Meyer, Tobias .

JOURNAL OF CELL SCIENCE, 2008, 121 (09) :1488-1494

[2] The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].

Backer, Jonathan M. .

BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17

[3] AN ESSENTIAL ROLE FOR A PHOSPHOLIPID TRANSFER PROTEIN IN YEAST GOLGI FUNCTION [J].

BANKAITIS, VA ;

AITKEN, JR ;

CLEVES, AE ;

DOWHAN, W .

NATURE, 1990, 347 (6293) :561-562

[4] Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway [J].

Blondeau, F ;

Laporte, J ;

Bodin, S ;

Superti-Furga, G ;

Payrastre, B ;

Mandel, JL .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2223-2229

[5] Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p [J].

Bonangelino, CJ ;

Nau, JJ ;

Duex, JE ;

Brinkman, M ;

Wurmser, AE ;

Gary, JD ;

Emr, SD ;

Weisman, LS .

JOURNAL OF CELL BIOLOGY, 2002, 156 (06) :1015-1028

[6] Retromer [J].

Bonifacino, Juan S. ;

Hurley, James H. .

CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (04) :427-436

[7] Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase [J].

Botelho, Roberto J. ;

Efe, Jem A. ;

Teis, David ;

Emr, Scott D. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (10) :4273-4286

[8] Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking [J].

Cao, Canhong ;

Backer, Jonathan M. ;

Laporte, Jocelyn ;

Bedrick, Edward J. ;

Wandinger-Ness, Angela .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (08) :3334-3346

[9] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes [J].

Cao, Canhong ;

Laporte, Jocelyn ;

Backer, Jonathan M. ;

Wandinger-Ness, Angela ;

Stein, Mary-Pat .

TRAFFIC, 2007, 8 (08) :1052-1067

[10] Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J [J].

Chow, Clement Y. ;

Zhang, Yanling ;

Dowling, James J. ;

Jin, Natsuko ;

Adamska, Maja ;

Shiga, Kensuke ;

Szigeti, Kinga ;

Shy, Michael E. ;

Li, Jun ;

Zhang, Xuebao ;

Lupski, James R. ;

Weisman, Lois S. ;

Meisler, Miriam H. .

NATURE, 2007, 448 (7149) :68-72

← 1 2 3 4 5 6 7 →