The medicinal chemistry of carboranes

被引：602

作者：

Valliant, JF ^{[1
]}

Guenther, KJ ^{[1
]}

King, AS ^{[1
]}

Morel, P ^{[1
]}

Schaffer, P ^{[1
]}

Sogbein, OO ^{[1
]}

Stephenson, KA ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

来源：

COORDINATION CHEMISTRY REVIEWS | 2002年 / 232卷 / 1-2期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

carboranes; medicinal; BNCT; BNCS; imaging; pharmaceuticals;

D O I：

10.1016/S0010-8545(02)00087-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The medicinal chemistry of dicarba-closo-dodecaboranes (otherwise referred to as carboranes) has traditionally centered on their use in boron neutron capture therapy (BNCT). More recently, work has begun to exploit the unique chemical and physical properties of carboranes for the preparation of novel inorganic pharmaceuticals and biological probes. This review is designed to highlight some of the recent work concerning medicinal carborane chemistry including the synthesis and testing of new BNCT agents. Following this review, as an appendix, is an illustrated summary of reactions involving carboranes reported in literature since 1992. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：173 / 230

页数：58

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