Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens

被引:711
作者
Nicola, SM [1 ]
Surmeier, DT
Malenka, RC
机构
[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[2] Northwestern Univ, Sch Med, Dept Physiol, Chicago, IL 60611 USA
[3] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
关键词
basal ganglia; dopamine; electrophysiology; synaptic transmission; ion conductances;
D O I
10.1146/annurev.neuro.23.1.185
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated behaviors depend on intact dopaminergic innervation. However, the mechanisms by which dopamine modulates neuronal function in the striatum and nucleus accumbens have been difficult to elucidate. Recent electrophysiological studies have revealed that dopamine alters both voltage-dependent conductances and synaptic transmission, resulting in state-dependent modulation of target cells. These studies make clear predictions about how dopamine, particularly via D-1 receptor activation, should alter the responsiveness of striatal neurons to extrinsic excitatory synaptic activity.
引用
收藏
页码:185 / 215
页数:31
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