neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities

被引：91

作者：

Dai, Sheng-Jun ^{[1
]}

Tao, Jia-Yi ^{[1
]}

Liu, Ke ^{[1
]}

Jiang, Yong-Tao ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 13期

关键词：

Scutellaria barbata D. Don; Labiatae; neo-clerodane diterpenoid; barbatins A-C; scutebarbatine B; cytotoxic activity;

D O I：

10.1016/j.phytochem.2006.04.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three neo-clerodane diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with ICSO values in the range 3.5-8.1 mu M. (c) 2006 Published by Elsevier Ltd.

引用

页码：1326 / 1330

页数：5

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