Application of the random forest classification algorithm to a SELDI-TOF proteomics study in the setting of a cancer prevention trial

被引：90

作者：

Izmirlian, G ^{[1
]}

机构：

[1] NCI, DHHS, Div Canc Prevent, Biometry Res Grp, Rockville, MD 20852 USA

来源：

APPLICATIONS OF BIOINFORMATICS IN CANCER DETECTION | 2004年 / 1020卷

关键词：

random forest (RF) algorithm; SELDI-TOF; cancer; classifier; classification tree (CT); detection; prevention; MDM; statistic;

D O I：

10.1196/annals.1310.015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A thorough discussion of the random forest (RF) algorithm as it relates to a SELDI-TOF proteomics study is presented, with special emphasis on its application for cancer prevention: specifically, what makes it an efficient, yet reliable classifier, and what makes it optimal among the many available approaches. The main body of the paper treats the particulars of how to successfully apply the RF algorithm in a proteomics profiling study to construct a classifier and discover peak intensities most likely responsible for the separation between the classes.

引用

页码：154 / 174

页数：21

共 22 条

[11]

Elwood M, 2002, LANCET, V360, P170, DOI 10.1016/S0140-6736(02)09389-3

[12]

Hastie T., 2009, ELEMENTS STAT LEARNI

[13]

LIAW A, 2003, RANDOM FOREST PACKAG

[14] Use of proteomic patterns in serum to identify ovarian cancer [J].

Petricoin, EF ;

Ardekani, AM ;

Hitt, BA ;

Levine, PJ ;

Fusaro, VA ;

Steinberg, SM ;

Mills, GB ;

Simone, C ;

Fishman, DA ;

Kohn, EC ;

Liotta, LA .

LANCET, 2002, 359 (9306) :572-577

[15]

Pollack A., 2004, NY TIMES, P1

[16]

Rockhill B, 2002, LANCET, V360, P169, DOI 10.1016/S0140-6736(02)09387-X

[17]

SVETNIK V, 2003, COMMUNICATION

[18] Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data [J].

Wu, BL ;

Abbott, T ;

Fishman, D ;

McMurray, W ;

Mor, G ;

Stone, K ;

Ward, D ;

Williams, K ;

Zhao, HY .

BIOINFORMATICS, 2003, 19 (13) :1636-1643

[19] Proteomic patterns of tumour subsets in non-small-cell lung cancer [J].

Yanagisawa, K ;

Shyr, Y ;

Xu, BGJ ;

Massion, PP ;

Larsen, PH ;

White, BC ;

Roberts, JR ;

Edgerton, M ;

Gonzalez, A ;

Nadaf, S ;

Moore, JH ;

Caprioli, RM ;

Carbone, DP .

LANCET, 2003, 362 (9382) :433-439

[20] SELDI ProteinChip® Array in Oncoproteomic Research [J].

Yip, Tai-Tung ;

Lomas, Lee .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2002, 1 (04) :273-279

← 1 2 3 →