The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in the Gambia

被引：51

作者：

Corran, PH

O'Donnell, RA

Todd, J

Uthaipibull, C

Holder, AA

Crabb, BS

Riley, EM

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

[3] Natl Inst Biol Stand & Controls, Immunobiol Div, S Mimms, Herts, England

[4] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/IAI.72.10.6185-6189.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of greater than or equal to1,000 parasites/mul than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.

引用

收藏

页码：6185 / 6189

页数：5

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