Haemoglobin: NO transporter, NO inactivator or NOne of the above?

被引：61

作者：

Hobbs, AJ

Gladwin, MT

Patel, RP

Williams, DLH

Butler, AR

机构：

[1] UCL, Wolfson Inst Biomed Res, London WC1E 6AE, England

[2] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA

[3] Univ Alabama Birmingham, Dept Pathol, Ctr Free Rad Biol, Birmingham, AL 35294 USA

[4] Univ Durham, Dept Chem, Durham DH1 3LE, England

[5] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[6] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 09期

关键词：

D O I：

10.1016/S0165-6147(02)02067-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The structural and functional characterization of haemoglobin (Hb) exceeds that of any other mammalian protein. Recently, the biological role attributed to Hb has been extended from the classical role in the transport and exchange of the respiratory gases O-2 and CO2 to include a third gaseous molecule, nitric oxide (NO). It is postulated that Hb might be involved in the systemic transport and delivery of NO to tissues and in the facilitation of O-2 release. However, definitive evidence for these putative activities is yet to be produced and many questions remain. Here we describe the present status of these hypotheses and their strengths and weaknesses.

引用

收藏

页码：406 / 411

页数：6

相关论文

共 60 条

[1] Superoxide produced in the heme pocket of the β-chain of hemoglobin reacts with the β-93 cysteine to produce a thiyl radical [J].

Balagopalakrishna, C ;

Abugo, OO ;

Horsky, J ;

Manoharan, PT ;

Nagababu, E ;

Rifkind, JM .

BIOCHEMISTRY, 1998, 37 (38) :13194-13202

[2] Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses [J].

Bellamy, TC ;

Wood, J ;

Goodwin, DA ;

Garthwaite, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2928-2933

[3] SIMULTANEOUS MEASUREMENTS OF CA2+ AND NITRIC-OXIDE IN BRADYKININ-STIMULATED VASCULAR ENDOTHELIAL-CELLS [J].

BLATTER, LA ;

TAHA, Z ;

MESAROS, S ;

SHACKLOCK, PS ;

WIER, WG ;

MALINSKI, T .

CIRCULATION RESEARCH, 1995, 76 (05) :922-924

[4] Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin [J].

Bonaventura, C ;

Ferruzzi, G ;

Tesh, S ;

Stevens, RD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (35) :24742-24748

[5] Diffusion of nitric oxide and scavenging by blood in the vasculature [J].

Butler, AR ;

Megson, IL ;

Wright, PG .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1998, 1425 (01) :168-176

[6] Effects of inhaled oxide on regional blood flow are consistent with intravascular nitric oxide delivery [J].

Cannon, RO ;

Schechter, AN ;

Panza, JA ;

Ognibene, FP ;

Pease-Fye, ME ;

Waclawiw, MA ;

Shelhamer, JH ;

Gladwin, MT .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (02) :279-287

[7] Nitric oxide and iron proteins [J].

Cooper, CE .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1411 (2-3) :290-309

[8] Effects of S-nitrosation of hemoglobin on hypoxic pulmonary vasoconstriction and nitric oxide flux [J].

Deem, S ;

Gladwin, MT ;

Berg, JT ;

Kerr, ME ;

Swenson, ER .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (05) :1164-1170

[9] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation [J].

Dimmeler, S ;

Fleming, I ;

Fisslthaler, B ;

Hermann, C ;

Busse, R ;

Zeiher, AM .

NATURE, 1999, 399 (6736) :601-605

[10] Mechanism of NO-induced oxidation of myoglobin and hemoglobin [J].

Eich, RF ;

Li, TS ;

Lemon, DD ;

Doherty, DH ;

Curry, SR ;

Aitken, JF ;

Mathews, AJ ;

Johnson, KA ;

Smith, RD ;

Phillips, GN ;

Olson, JS .

BIOCHEMISTRY, 1996, 35 (22) :6976-6983

← 1 2 3 4 5 6 →