Inhibition of angiogenesis and murine tumour growth by laminarin sulphate

被引：30

作者：

Hoffman, R

Paper, DH

Donaldson, J

Vogl, H

机构：

[1] MRC CTR,CLIN ONCOL & RADIOTHERAPEUT UNIT,CAMBRIDGE CB2 2QH,ENGLAND

[2] UNIV REGENSBURG,DEPT PHARM,D-93040 REGENSBURG,GERMANY

来源：

BRITISH JOURNAL OF CANCER | 1996年 / 73卷 / 10期

关键词：

angiogenesis; laminarin sulphate; anti-tumour;

D O I：

10.1038/bjc.1996.228

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LAM S5 is a polysulphated derivative of the glucan laminarin that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P=0.01).

引用

页码：1183 / 1186

页数：4

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JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (22) :1716-1724

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