Ontogeny of early life immunity

被引：285

作者：

Dowling, David J. ^{[1
,2
]}

Levi, Ofer ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 07期

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

PNEUMOCOCCAL CONJUGATE VACCINE; RECENT THYMIC EMIGRANTS; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; DENDRITIC CELLS; NEONATAL MICE; ADAPTIVE IMMUNITY; HUMAN NEWBORN; SYSTEMATIC ANALYSIS; CYTOKINE RESPONSES;

D O I：

10.1016/j.it.2014.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The human immune system comprises cellular and molecular components designed to coordinately prevent infection while avoiding potentially harmful inflammation and autoimmunity. Immunity varies with age, reflecting unique age-dependent challenges including fetal gestation, the neonatal phase, and infancy. Here, we review novel mechanistic insights into early life immunity, with an emphasis on emerging models of human immune ontogeny, which may inform age-specific translational development of novel anti-infectives, immunomodulators, and vaccines.

引用

页码：299 / 310

页数：12

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