The inhibitory effect of UVB irradiation on the expression of p53 and Ki-67 proteins in arsenic-induced Bowen's disease

被引：11

作者：

Chai, CY

Yu, HS

Yen, HT

Tsai, KB

Chen, GS

Yu, CL

机构：

[1] KAOHSIUNG MED COLL,DEPT DERMATOL,KAOHSIUNG 807,TAIWAN

[2] KAOHSIUNG MED COLL,DEPT PATHOL,KAOHSIUNG 807,TAIWAN

[3] KAOHSIUNG MED COLL,GRAD INST MED SCI,KAOHSIUNG 807,TAIWAN

[4] VET GEN HOSP,DEPT MED,TAIPEI,TAIWAN

[5] NATL YANG MING UNIV,SCH MED,TAIPEI 112,TAIWAN

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 1997年 / 24卷 / 01期

关键词：

D O I：

10.1111/j.1600-0560.1997.tb00779.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aim of this study is to evaluate the effect of ultraviolet B (WB) on arsenic-induced Bowen's disease. Four patients were irradiated with 750 mJ/cm(2) of UVB and biopsies were performed before treatment and 2 weeks later. Immunohistochemical stains of p53 and Ki-67 were compared by the labelled-streptavidin method before and after the UVB treatment. We found that the number of p53 and Ki-67 positive cells after the UVB treatment were significantly fewer than those of non-UVB-treated specimens. These results suggest that the UVB inhibitory effect in Bowen's disease needs further studies to clarify its value in potentially retarding the progression of the hyperproliferative status in overt skin cancer on a molecular basis. (C) Munksgaard 1997.

引用

页码：8 / 13

页数：6

共 26 条

[1] A ROLE FOR SUNLIGHT IN SKIN-CANCER - UV-INDUCED P53 MUTATIONS IN SQUAMOUS-CELL CARCINOMA [J].