Nutrition Status Predicts Severity of Vascular Calcification in Non-Dialyzed Chronic Kidney Disease

被引：28

作者：

Harada, Kazuhiro ^{[1
]}

Suzuki, Susumu ^{[1
]}

Ishii, Hideki ^{[1
]}

Hirayama, Kenshi ^{[1
]}

Aoki, Toshijiro ^{[1
]}

Shibata, Yohei ^{[1
]}

Negishi, Yosuke ^{[1
]}

Sumi, Takuya ^{[1
]}

Kawashima, Kazuhiro ^{[1
]}

Kunimura, Ayako ^{[1
]}

Tatami, Yosuke ^{[1
]}

Kawamiya, Toshiki ^{[1
]}

Yamamoto, Dai ^{[1
]}

Morimoto, Ryota ^{[1
,2
]}

Yasuda, Yoshinari ^{[2
]}

Murohara, Toyoaki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan

[2] Nagoya Univ, Grad Sch Med, Dept CKD Initiat Internal Med, Nagoya, Aichi, Japan

来源：

CIRCULATION JOURNAL | 2017年 / 81卷 / 03期

关键词：

Aortic calcification index; Geriatric nutritional risk index; Nutrition status; ABDOMINAL AORTIC CALCIFICATION; CORONARY-ARTERY CALCIFICATION; RISK INDEX; CARDIOVASCULAR OUTCOMES; MORTALITY; INFLAMMATION; MALNUTRITION; PROGRESSION; CALCIUM; IMPACT;

D O I：

10.1253/circj.CJ-16-0911

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Vascular calcification is a major complication in chronic kidney disease (CKD) that increases the risk of adverse clinical outcomes. Geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that predicts poor prognosis in elderly subjects. The purpose of the present study was to evaluate the correlation between GNRI and severity of vascular calcification in non-dialyzed CKD patients. Methods and Results: We enrolled 323 asymptomatic CKD patients. To evaluate abdominal aortic calcification (AAC), we used aortic calcification index (ACI) determined on non-contrast computed tomography. The patients were divided into three groups according to GNRI tertile. Median ACI significantly decreased with increasing GNRI tertile (15.5%, 13.6%, and 7.9%, respectively; P= 0.001). On multivariate regression analysis GNRI was significantly correlated with ACI (beta=-0.15, P= 0.009). We also investigated the combination of GNRI and C-reactive-protein (CRP) for predicting the severity of AAC. Low GNRI and high CRP were significantly associated with severe AAC, compared with high GNRI and low CRP (OR, 4.07; P= 0.004). Conclusions: GNRI was significantly associated with AAC in non-dialyzed CKD patients.

引用

页码：316 / 321

页数：6

共 26 条

[1]

The Malnutrition Inflammation Complex Syndrome-The Micsing Factor in the Perio-Chronic Kidney Disease Interlink [J].