Molecular biology of upper gastrointestinal malignancies

被引：58

作者：

Lin, J ^{[1
]}

Beer, DG ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Sect Gen Thorac Surg, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN ONCOLOGY | 2004年 / 31卷 / 04期

关键词：

D O I：

10.1053/j.seminoncol.2004.04.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

While cancers of the upper gastrointestinal tract are related by location, they have distinct clinical and molecular characteristics. This review will focus on the molecular biology of esophageal adenocarcinoma (EAC) of which alterations in p53, overexpression of cyclin D1, loss of p16, and aneuploidy have been best characterized. Key similarities and differences, when compared to esophageal squamous cell carcinoma (ESCC), gastric adenocarcinoma (GC), and adenocarcinoma of the gastric cardia (AGC), will also be highlighted. Currently, malignancies of the upper gastrointestinal tract are often diagnosed at an advanced stage and are generally associated with a poor patient prognosis. With an improved understanding of the molecular biology of these tumors, there is hope that new targets for diagnosis, chemoprevention, and therapy will be developed. © 2004 Elsevier Inc. All rights reserved.

引用

页码：476 / 486

页数：11

共 81 条

[1]

Anayama T, 1998, INT J CANCER, V79, P439, DOI 10.1002/(SICI)1097-0215(19980821)79:4<439::AID-IJC22>3.0.CO

[2]

2-Z

[3]

Arber N, 1996, CANCER EPIDEM BIOMAR, V5, P457

[4] Cellular and molecular mechanisms responsible for progression of Barrett's metaplasia to esophageal carcinoma [J].

Beilstein, M ;

Silberg, D .

GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2002, 31 (02) :461-+

[5] E-CADHERIN EXPRESSION IN PRIMARY AND METASTATIC THORACIC NEOPLASMS AND IN BARRETTS-ESOPHAGUS [J].

BONGIORNO, PF ;

ALKASSPOOLES, M ;

LEE, SW ;

RACHWAL, WJ ;

MOORE, JH ;

WHYTE, RI ;

ORRINGER, MB ;

BEER, DG .

BRITISH JOURNAL OF CANCER, 1995, 71 (01) :166-172

[6] LOSS OF HETEROZYGOSITY INVOLVING THE APC AND MCC GENETIC-LOCI OCCURS IN THE MAJORITY OF HUMAN ESOPHAGEAL CANCERS [J].

BOYNTON, RF ;

BLOUNT, PL ;

YIN, J ;

BROWN, VL ;

HUANG, Y ;

TONG, Y ;

MCDANIEL, T ;

NEWKIRK, C ;

RESAU, JH ;

RASKIND, WH ;

HAGGITT, RC ;

REID, BJ ;

MELTZER, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3385-3388

[7]

Cameron AJ, 1997, AM J GASTROENTEROL, V92, P586

[8]

Casson AG, 1997, INT J CANCER, V72, P739, DOI 10.1002/(SICI)1097-0215(19970904)72:5<739::AID-IJC6>3.0.CO

[9]

2-T

[10] p53 alterations in oesophageal cancer: association with clinicopathological features, risk factors, and survival [J].

Casson, AG ;

Tammemagi, M ;

Eskandarian, S ;

Redston, M ;

McLaughlin, J ;

Ozcelik, H .

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 1998, 51 (02) :71-79

← 1 2 3 4 5 6 7 8 9 →