Molecular biology of upper gastrointestinal malignancies

被引：58

作者：

Lin, J ^{[1
]}

Beer, DG ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Sect Gen Thorac Surg, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN ONCOLOGY | 2004年 / 31卷 / 04期

关键词：

D O I：

10.1053/j.seminoncol.2004.04.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

While cancers of the upper gastrointestinal tract are related by location, they have distinct clinical and molecular characteristics. This review will focus on the molecular biology of esophageal adenocarcinoma (EAC) of which alterations in p53, overexpression of cyclin D1, loss of p16, and aneuploidy have been best characterized. Key similarities and differences, when compared to esophageal squamous cell carcinoma (ESCC), gastric adenocarcinoma (GC), and adenocarcinoma of the gastric cardia (AGC), will also be highlighted. Currently, malignancies of the upper gastrointestinal tract are often diagnosed at an advanced stage and are generally associated with a poor patient prognosis. With an improved understanding of the molecular biology of these tumors, there is hope that new targets for diagnosis, chemoprevention, and therapy will be developed. © 2004 Elsevier Inc. All rights reserved.

引用

页码：476 / 486

页数：11

共 81 条

[11]

CASSON AG, 1991, J THORAC CARDIOV SUR, V102, P707

[12]

Casson Alan G, 2002, Chest Surg Clin N Am, V12, P93, DOI 10.1016/S1052-3359(03)00068-1

[13]

Chanvitan A, 1997, Dis Esophagus, V10, P206

[14] Significance of Fas and retinoblastoma protein expression during the progression of Barrett's metaplasia to adenocarcinoma [J].

Coppola, D ;

Schreiber, RH ;

Mora, L ;

Dalton, W ;

Karl, RC .

ANNALS OF SURGICAL ONCOLOGY, 1999, 6 (03) :298-304

[15] Is Barrett's esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study [J].

deAlmeida, JC ;

Chaves, P ;

Pereira, AD ;

Altorki, NK .

ANNALS OF SURGERY, 1997, 226 (06) :725-733

[16]

Devesa SS, 1998, CANCER, V83, P2049, DOI 10.1002/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.3.CO

[17]

2-U

[18] Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites [J].

Dolan, K ;

Garde, J ;

Gosney, J ;

Sissons, M ;

Wright, T ;

Kingsnorth, AN ;

Walker, SJ ;

Sutton, R ;

Meltzer, SJ ;

Field, JK .

BRITISH JOURNAL OF CANCER, 1998, 78 (07) :950-957

[19] STABILITY OF BIPOLAR II AFFECTIVE-DISORDER AS A DIAGNOSTIC ENTITY [J].

DUNNER, DL .

PSYCHIATRIC ANNALS, 1987, 17 (01) :18-20

[20] Pathogenesis of sporadic and familial gastric cancer - implications for clinical management and cancer prevention [J].

Ebert, MPA ;

Malfertheiner, P .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (06) :1059-1066

← 1 2 3 4 5 6 7 8 9 →