Neutrophil infiltration and chemokines

被引：148

作者：

Kobayashi, Yoshiro ^{[1
]}

机构：

[1] Toho Univ, Dept Biomol Sci, Div Mol Med, Chiba 2748510, Japan

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2006年 / 26卷 / 04期

关键词：

IL-8; MIP-2; KC; macrophage; neutrophil; CXCR2;

D O I：

10.1615/CritRevImmunol.v26.i4.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophil infiltration is mainy mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models. I also illustrate how these three chemokines are induced and how they are involved in neutrophil infiltration. Finally, I introduce synthetic compounds with high efficacy in the prevention of ischemia reperfusion injury.

引用

页码：307 / 315

页数：9

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