Neutrophil infiltration is mainy mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models. I also illustrate how these three chemokines are induced and how they are involved in neutrophil infiltration. Finally, I introduce synthetic compounds with high efficacy in the prevention of ischemia reperfusion injury.
机构:Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
Miotla, JM
;
Ridger, VC
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机构:Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
Ridger, VC
;
Hellewell, PG
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h-index: 0
机构:
Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, EnglandUniv Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
机构:Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
Miotla, JM
;
Ridger, VC
论文数: 0引用数: 0
h-index: 0
机构:Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
Ridger, VC
;
Hellewell, PG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, EnglandUniv Sheffield, Ctr Clin Sci, No Gen Hosp, Div Clin Sci,Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England