The toxicity of antioxidants and their metabolites

被引：109

作者：

Bast, A ^{[1
]}

Haenen, GRMM ^{[1
]}

机构：

[1] Maastricht Univ, Dept Pharmacol & Toxicol, Fac Med, NL-6200 MD Maastricht, Netherlands

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2002年 / 11卷 / 3-4期

关键词：

vitamin E; beta-carotene; lipoic acid; antioxidant; toxicity; safety;

D O I：

10.1016/S1382-6689(01)00118-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Antioxidants are used on a very large scale to try to obtain and preserve optimal health. Nutraceuticals and food supplements frequently contain huge dosages of antioxidants. It is not generally recognised that high intake of antioxidants may also have adverse effects. Three antioxidants i.e. vitamin E, beta-carotene and lipoic acid are used to illustrate general considerations on the toxicity of antioxidants. Based on the examples the following recommendations for the evaluation of the toxicity of antioxidants are made: (i) classical safety factors should not be used. (ii) Knowledge on the mechanism of the efficacy and toxicity of antioxidants should be increased. (iii) Bio-kinetic/bio-efficacy modelling might be of help to optimise dosage. (iv) When antioxidant supplementation changes into therapy, a more accurate risk/benefit analyses is warranted. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：251 / 258

页数：8

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[21] VITAMIN-E IS A COMPLETE TUMOR PROMOTER IN MOUSE SKIN [J].