Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents

被引:96
作者
Kim, J-S [1 ]
Jang, I-K [2 ]
Kim, J-S [1 ]
Kim, T. H. [1 ]
Takano, M. [3 ]
Kume, T. [4 ]
Hur, N. W.
Ko, Y-G [1 ]
Choi, D. [1 ]
Hong, M-K [1 ]
Jang, Y. [1 ]
机构
[1] Yonsei Univ, Coll Med, Div Cardiol, Yonsei Cardiovasc Ctr, Seoul 120752, South Korea
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA
[3] Nippon Med Sch, Div Cardiol, Tokyo 113, Japan
[4] Kawasaki Med Sch, Dept Cardiol, Kurashiki, Okayama, Japan
关键词
NEOINTIMAL COVERAGE; BARE-METAL; THROMBOSIS;
D O I
10.1136/hrt.2009.167759
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the vascular response at 9 months after zotarolimus-eluting stent (ZES; Endeavor) implantation using optical coherence tomography (OCT). These findings were compared with those after implantation of a sirolimus-eluting stent (SES; Cypher Select). Design: Cross-sectional observational study with prospective OCT registry. Setting: Nine months after ZES or SES implantation. Patients and methods: A total of 68 patients (32 ZES and 36 SES) underwent OCT at 9 months after stent implantation. The neointima hyperplasia (NIH) thickness inside each strut and percentage of NIH area at every 1 mm cross section were measured. Main outcome measurement: The degree of neointimal coverage and the prevalence of malapposition at 9 months after ZES and SES implantation using OCT. Results: The mean (SD) NIH thickness (251.2 (110.0) mu m vs 85.5 (53.3) mu m, p < 0.001) and percentage of NIH area (27.9 (9.1)% vs 11.2 (7.1)%, p < 0.001) were significantly greater in ZES than in SES. The prevalence of uncovered strut as well as malapposed strut was significantly lower in ZES than in SES (0.3% vs 12.3%, p < 0.001 and 0.08% vs 2.6%, p < 0.001). Thrombus was not observed in ZES (0.0% in ZES vs 27.8% in SES, p = 0.001). Conclusions: Neointimal coverage in ZES was almost complete and malapposition was very rare at 9-months' follow-up.
引用
收藏
页码:1907 / 1912
页数:6
相关论文
共 22 条
[1]   Angioscopic comparison of neointimal coverage between zotarolimus- and sirolimus-eluting stents [J].
Awata, Masaki ;
Nanto, Shinsuke ;
Uematsu, Masaaki ;
Morozumi, Takakazu ;
Watanabe, Tetsuya ;
Onishi, Toshinari ;
Iida, Osamu ;
Sera, Fusako ;
Kotani, Jun-ichi ;
Hori, Masatsugu ;
Nagata, Seiki .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (09) :789-790
[2]   A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents [J].
Babapulle, MN ;
Joseph, L ;
Bélisle, P ;
Brophy, JM ;
Eisenberg, MJ .
LANCET, 2004, 364 (9434) :583-591
[3]   Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography [J].
Chen, B. X. ;
Ma, F. Y. ;
Luo, W. ;
Ruan, J. H. ;
Xie, W. L. ;
Zhao, X. Z. ;
Sun, S. H. ;
Guo, X. M. ;
Wang, F. ;
Tian, T. ;
Chu, X. W. .
HEART, 2008, 94 (05) :566-570
[4]   Incomplete stent apposition and very late stent thrombosis after drug-eluting stent implantation [J].
Cook, Stephane ;
Wenaweser, Peter ;
Togni, Mario ;
Billinger, Michael ;
Morger, Cyrill ;
Seiler, Christian ;
Vogel, Rolf ;
Hess, Otto ;
Meier, Bernhard ;
Windecker, Stephan .
CIRCULATION, 2007, 115 (18) :2426-2434
[5]   Pathological mechanisms of fatal late coronary stent thrombosis in humans [J].
Farb, A ;
Burke, AP ;
Kolodgie, FD ;
Virmani, R .
CIRCULATION, 2003, 108 (14) :1701-1706
[6]   Pathological correlates of late drug-eluting stent thrombosis - Strut coverage as a marker of endothelialization [J].
Finn, Aloke V. ;
Joner, Michael ;
Nakazawa, Gaku ;
Kolodgie, Frank ;
Newell, John ;
John, Mike C. ;
Gold, Herman K. ;
Virmani, Renu .
CIRCULATION, 2007, 115 (18) :2435-2441
[7]  
GUAGLIUMI GMG, 2008, AM J CARDIOL, V102
[8]   Impact of late drug-eluting stent malapposition on 3-year clinical events [J].
Hong, Myeong-Ki ;
Mintz, Gary S. ;
Lee, Cheol Whan ;
Park, Duk-Woo ;
Lee, Seung-Whan ;
Kim, Young-Hak ;
Kang, Duk-Hyun ;
Cheong, Sang-Sig ;
Song, Jae-Kwan ;
Kim, Jae-Joong ;
Park, Seong-Wook ;
Park, Seung-Jung .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (15) :1515-1516
[9]   Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound [J].
Jang, IK ;
Bouma, BE ;
Kang, DH ;
Park, SJ ;
Park, SW ;
Seung, KB ;
Choi, KB ;
Shishkov, M ;
Schlendorf, K ;
Pomerantsev, E ;
Houser, SL ;
Aretz, HT ;
Tearney, GJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) :604-609
[10]   Stent thrombosis after successful sirolimus-eluting stent implantation [J].
Jeremias, A ;
Sylvia, B ;
Bridges, J ;
Kirtane, AJ ;
Bigelow, B ;
Pinto, DS ;
Ho, KKL ;
Cohen, DJ ;
Garcia, LA ;
Cutlip, DE ;
Carrozza, JP .
CIRCULATION, 2004, 109 (16) :1930-1932