Mitochondrial involvement in the ageing process. Facts and controversies

被引：34

作者：

Brierley, EJ

Johnson, MA

James, OFW

Turnbull, DM

机构：

[1] SCH MED,DEPT GERIATR MED,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

[2] SCH MED,DEPT NEUROBIOL,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1997年 / 174卷 / 1-2期

基金：

英国惠康基金;

关键词：

ageing; theory; mitochondria; respiratory chain; mitochondrial DNA mutations;

D O I：

10.1023/A:1006847319162

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria are believed to be involved in human ageing. Whilst it is clear that various mitochondrial DNA mutations do accumulate in human tissues with age, whether or not they interfere with respiratory chain function is uncertain. We question the results of previous studies which have measured respiratory chain function in human skeletal muscle with age. Whilst cytochrome c oxidase deficient fibres are a real finding in skeletal muscle, the contribution of mitochondrial DNA mutations to human ageing is still controversial. Our results show for mitochondria to be involved in ageing then it must be through a more subtle mechanism than a global decline in respiratory chain function.

引用

页码：325 / 328

页数：4

共 30 条

[21] DIFFERENT INSITU HYBRIDIZATION PATTERNS OF MITOCHONDRIAL-DNA IN CYTOCHROME-C OXIDASE-DEFICIENT EXTRAOCULAR-MUSCLE FIBERS IN THE ELDERLY
MULLERHOCKER, J
SEIBEL, P
SCHNEIDERBANGER, K
KADENBACH, B
[J]. VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1993, 422 (01) : 7 - 15
[22] THE POINT MUTATION OF MITOCHONDRIAL-DNA CHARACTERISTIC FOR MERRF DISEASE IS FOUND ALSO IN HEALTHY PEOPLE OF DIFFERENT AGES
MUNSCHER, C
RIEGER, T
MULLERHOCKER, J
KADENBACH, B
[J]. FEBS LETTERS, 1993, 317 (1-2) : 27 - 30
[23] QUANTITATIVE-DETERMINATION OF DELETED MITOCHONDRIAL-DNA RELATIVE TO NORMAL DNA IN PARKINSONIAN STRIATUM BY A KINETIC PCR ANALYSIS
OZAWA, T
TANAKA, M
IKEBE, S
OHNO, K
KONDO, T
MIZUNO, Y
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 172 (02) : 483 - 489
[24] NORMAL OXIDATIVE DAMAGE TO MITOCHONDRIAL AND NUCLEAR-DNA IS EXTENSIVE
RICHTER, C
PARK, JW
AMES, BN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (17) : 6465 - 6467
[25] DISTRIBUTION OF WILD-TYPE AND COMMON DELETION FORMS OF MTDNA IN NORMAL AND RESPIRATION-DEFICIENT MUSCLE-FIBERS FROM PATIENTS WITH MITOCHONDRIAL MYOPATHY
SCIACCO, M
BONILLA, E
SCHON, EA
DIMAURO, S
MORAES, CT
[J]. HUMAN MOLECULAR GENETICS, 1994, 3 (01) : 13 - 19
[26] OXIDATIVE DAMAGE AND MITOCHONDRIAL DECAY IN AGING
SHIGENAGA, MK
HAGEN, TM
AMES, BN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) : 10771 - 10778
[27] ACCUMULATION OF DELETIONS IN HUMAN MITOCHONDRIAL-DNA DURING NORMAL AGING - ANALYSIS BY QUANTITATIVE PCR
SIMONETTI, S
CHEN, X
DIMAURO, S
SCHON, EA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1180 (02) : 113 - 122
[28] DECLINE IN SKELETAL-MUSCLE MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION - POSSIBLE FACTOR IN AGING
TROUNCE, I
BYRNE, E
MARZUKI, S
[J]. LANCET, 1989, 1 (8639) : 637 - 639
[29] TURNBULL DM, 1982, BIOCHEM J, V206, P511, DOI 10.1042/bj2060511
[30] MULTIPLE MITOCHONDRIAL-DNA DELETIONS IN AN ELDERLY HUMAN INDIVIDUAL
ZHANG, C
BAUMER, A
MAXWELL, RJ
LINNANE, AW
NAGLEY, P
[J]. FEBS LETTERS, 1992, 297 (1-2) : 34 - 38

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