Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro

被引：133

作者：

Delaney, WE

Edwards, R

Colledge, D

Shaw, T

Furman, P

Painter, G

Locarnini, S

机构：

[1] Victorian Infect Dis Reference Lab, Melbourne, Vic 3051, Australia

[2] Triangle Pharmaceut, Durham, NC 27707 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 09期

关键词：

D O I：

10.1128/AAC.46.9.3057-3060.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 +/- 9.5 and 2.40 +/- 0.92 muM, respectively, compared to 0.064 +/- 0.020 muM lamivudine. There were no significant differences in sensitivity between wild-type and nucleoside analogue-resistant (rtL180M, rtM204I, and rtL180M + rtM204V) HBV.

引用

页码：3057 / 3060

页数：4

共 34 条

[31] Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region [J].