Spectrally weighted twisted projection imaging: Reducing T-2 signal attenuation effects in fast three-dimensional sodium imaging

A scheme for the reduction of T-2 signal attenuation effects in three-dimensional twisted projection imaging is presented, By purposely reducing the sample density at the high spatial frequencies, a considerable reduction in readout time is achieved. The reduction in readout time leads to decreased T-2 signal attenuation which translates into improved signal-to-noise ratio (SNR). The SNR improvement is achieved without decreasing the image's resolution since the point spread function depends on the sample weighting as Well as the T-2 attenuation, The results indicate that SNR improvements of up to 40% can be achieved using the proposed scheme.