The central half of Pit2 is not required for its function as a retroviral receptor

被引：14

作者：

Bottger, P

Pedersen, L

机构：

[1] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Inst Clin, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 17期

关键词：

D O I：

10.1128/JVI.78.17.9564-9567.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The type III sodium-dependent phosphate (NaPi) cotransporter, Pit2, is a receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV. In order to determine what is sufficient for Pit2 receptor function, a deletion mutant lacking about the middle half of the protein was made. The mutant supported entry for both viruses, unequivocally narrowing down the identification of the sequence that is sufficient to specify the receptor functions of Pit2 to its N-terminal 182 amino acids and C-terminal 170 amino acids.

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页码：9564 / 9567

页数：4

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